387 Genomic and epigenomic profiling of “invisible scar” in psoriatic resolved skin

Psoriasis is a common relapsing autoimmune skin disease. Effective treatment resolves cutaneous symptoms, but they often relapse in previously involved regions. Apart from T-cell-driven disease memory, pathogenic genetic and epigenetic memory of the structural cells has been suggested, however nature such plaque-site still under investigation. We aimed to perform pairwise comparison psoriatic never-lesional (PSO-NES) resolved (PSO-RES) identify genomic epigenomic differences, which may contribute formation localized clinically healed samples. To address these questions, we performed immunofluorescence staining visualize general pattern 5-Methylcytosine (5-mC) 5-Hydroxymethylcytosine (5-hmC) marks biopsy sections. also applied high-throughput RNA-seq profile transcriptional status epidermal dermal compartments. With confocal microscopic analysis, found that 5-mC 5-hmC intensities were overall lower PSO-RES compared with PSO-NES epidermis Our transcriptomic data showed diminished suppressor cytokine signaling 1 (SOCS1) expression vs. epidermis. observations suggest possibility reprogramming due reduction as functionally active modifications. These be consequence greater sensitivity keratinocytes inflammatory stimuli reduced levels downregulating factor, SOCS1.